Physics of multicellular systems

Accès rapides

Accès rapides

Prochain Séminaire de la FIP :
Accéder au programme

Retrouvez toutes les informations pour vos stages :
Stages L3
Stages M1 ICFP

Actualités : Séminaire de Recherche ICFP
du 14 au 18 novembre 2022 :

Retrouvez le programme complet

Contact - Secrétariat de l’enseignement :
Tél : 01 44 32 35 60
enseignement@phys.ens.fr

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Enseignants : Hervé Turlier (CNRS CdF) + Vincent Hakim (CNRS ENS)
Chargé de TD  :

Nombre d’ECTS : 3

Langue d’enseignement : Anglais

Modalité d’évaluation : study and presentation of a scientific article. Part of the mark will also be based on homework practical sessions. ORAL - Room Djebar

Description  : The development of animals, starting from a single cell to produce a fully formed organism, is a fascinating process. Its study is currently advancing at a rapid pace thanks to combined experimental and theoretical progress, with yet many fundamental questions remaining to be understood. Advances in sequencing, genetic manipulation, microscopy and ex-vivo culture are bringing unprecedented amount of detailed and quantitative information. Theory, models and numerical simulations build on physical concepts from diverse fields, such as statistical mechanics (particularly of out-of equilibrium systems such as active matter), soft-matter, dynamical systems, pattern formation, information theory and mechanics. Besides the understanding of animal development, much motivation is also coming from the hope of producing organs ex-vivo and to rationally design therapy for complex diseases.

The lectures will present an introduction to this burgeoning field of research at the broad interface of physics and biology. They will be accompanied by practical sessions (TDs) with both theoretical and numerical components.

Course outline

1) Introduction

2) Patterning I (gradient, positional information, physical limits,…)

3) Patterning II (auto-organization, Turing’s idea, ex-vivo cultures and organoids,…)

4) Interaction between cells, spontaneous symmetry breaking and lateral inhibition, dynamical system approach.

5) Cortical tension (origin, measurement : micropipette/AFM), vertex models (quasi-static) in 2D/3D, application to epithelia + early embryos, force inference

6) Active foam models : cell rearrangements, glassy dynamics, jamming

7) Dissipative models : active gels, dissipation potential, tension anisotropy and folding (in cells : cytokinesis, polarization) and tissues (epithelia).

8) Continuous models : tissue rheology, cell division/apoptosis, growth and homeostatic pressure, nematic order

9) Mechano-chemical coupling - self-organized surfaces (contractile waves, actomyosin patterning), mechano-chemical patterning at the tissue level, volume control).

10) Cellular motion , single and collective.

Accès rapides

Prochain Séminaire de la FIP :
Accéder au programme

Retrouvez toutes les informations pour vos stages :
Stages L3
Stages M1 ICFP

Actualités : Séminaire de Recherche ICFP
du 14 au 18 novembre 2022 :

Retrouvez le programme complet

Contact - Secrétariat de l’enseignement :
Tél : 01 44 32 35 60
enseignement@phys.ens.fr

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